关键词: 银马解毒颗粒, 便秘, 洛哌丁胺

Abstract: Objective The present study aims to study the therapeutic effect of Yinma Jiedu Granule on loperamideinduced constipation in mice. Method Male ICR mice were randomly divided into control group, model group and Yinma Jiedu Granule 500, 1 000 and 2 000 mg / kg groups. Mice were administrated with 500, 1 000 and 2 000 mg / kg of Yinma Jiedu Granule by gavage each day for continuous 8 days. Thirty minutes after the last administration, loperamide was orally given to induce constipation. Then the ink was intragastric administrated 30 minutes later. The large intestinal propulsion rate, total intestinal propulsion rate, number of black stools in the large intestine, the time of first black stool defecation and the number of defecation in an hour were recorded in each group of mice. Result Yinma Jiedu Granule 2 000 mg / kg could significantly increase the large intestinal propulsion rate and total intestinal propulsion rate, decrease the time of first black stool defecation, and increase the number of defecation within 1 hour compared with constipation of mice induced by loperamide. Conclusion Yinma Jiedu Granule could alleviate loperamide-induced constipation though improving the function of large intestine propulsion, shortening defecation time and increasing defecation volume in mice, suggesting that Yinma Jiedu Granule might be an effective drug for constipation treatment.

Key words: Yinma Jiedu Granule, constipation, loperamide